Description
Product Characteristics: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of LMNB1 in tissue homogenates, cell lysates. Due to the 95% homology of the sequence among different species, the kit can be used to detect human, mouse and rat samples.
Target Information: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). [provided by RefSeq, Oct 2010]